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This product is a combination of 2 medications: ibuprofen and pseudoephedrine. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, fever, and inflammation by reducing a substance in the body that leads to inflammation and pain. Pseudoephedrine is a decongestant that relieves the symptoms of nasal and sinus congestion by shrinking swollen nasal passages and sinuses.

This medication is used to relieve nasal congestion, sinus congestion, sinus pain, fever, headache, sore throat, and body aches and pains that are associated with the common cold, sinusitis, or the flu.

Your doctor or pharmacist may have suggested this medication for conditions other than the ones listed in this drug information article. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor or pharmacist.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor or pharmacist has not recommended it.

The usual recommended dose for adults and children older than 12 years is 1 or 2 caplets or liqui-gels every 4 to 6 hours as needed. Do not take more than 6 caplets or liqui-gels in 24 hours unless recommended by your doctor.

For the children’s suspension, the dose depends on the child’s age and weight and is given every 6 hours as needed. Do not give more than 4 doses a day unless recommended by your doctor. Use an oral syringe or medication cup to measure each dose of the suspension, as it gives a more accurate measurement than household teaspoons. Shake the suspension well before pouring a dose.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the one listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as recommended by your doctor or pharmacist. If you are taking this medication regularly and you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature and keep it out of the reach of children.

This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under “What form(s) does this medication come in?”

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Motrin Cold &Sinus Pain is no longer being manufactured for sale in Canada. For brands that may still be available, search under ibuprofen – pseudoephedrine. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.

Do not take this medication if you:

are allergic or sensitive to ibuprofen, pseudoephedrine, other NSAIDs (e.g., naproxen, ketoprofen, diclofenac), ASA, or any ingredients of the medication
are about to have or have just had heart surgery
are dehydrated due to vomiting, diarrhea, or not drinking enough fluids
are taking another NSAID (e.g., naproxen, diclofenac, ketoprofen)
are pregnant or breast-feeding
have a stomach ulcer, intestinal ulcer, ulcerative colitis, or Crohn’s disease
have angioedema syndrome
have experienced wheezing or difficulty breathing from ASA or other NSAIDs (e.g., naproxen, diclofenac, ketoprofen)
have kidney disease, reduced or worsening kidney function
have nasal polyps
have serious liver disease or reduced liver function
have severe heart disease
have severe high blood pressure
have systemic lupus erythematosus
have Raynaud’s Syndrome
have taken a monoamine oxidase (MAO) inhibitor (e.g., phenelzine, tranylcypromine) within the last 14 days
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

bloating or gas
decreased appetite
difficulty sleeping
heartburn and indigestion
stomach cramps
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

blurred vision or other eye symptoms
fast, pounding heartbeat (palpitations)
ringing in the ears
skin rash
weight gain
Stop taking the medication and seek immediate medical attention if any of the following occur:

black, tarry stools
blood in vomit
symptoms of a severe allergic reaction (difficulty breathing, hives, swelling of the mouth or throat)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

March 24, 2016
Health Canada has issued new restrictions concerning the use of ibuprofen – pseudoephedrine. To read the full Health Canada Advisory, visit Health Canada’s web site at

Bladder problems: This medication may cause bladder pain, painful or difficult urination, or increased frequency of urination. If these symptoms occur without an explanation (e.g., infection), stop taking this medication and contact your doctor.

Bleeding problems: If you have bleeding problems (e.g., hemophilia) or are taking anticoagulants (e.g., warfarin), you should not take this medication, unless recommended by your doctor.

Drowsiness and dizziness: This medication can cause drowsiness and dizziness that may affect your ability to drive or operate machinery safely. If this medication affects you this way, do not perform these tasks.

Fluid retention: This medication can cause fluid retention. If you have heart failure or high blood pressure, fluid retention may worsen your condition. If you notice worsening of the symptoms of heart failure or your blood pressure increases while taking this medication, contact your doctor.

General: If your symptoms do not improve contact your doctor. Do not use this medication for longer than 3 days for a fever or 5 days for pain or cold symptoms without consulting your doctor or pharmacist.

Kidney problems: This medication may cause kidney problems. If you have reduced kidney function, heart failure, are taking diuretics (e.g., hydrochlorothiazide, furosemide), or are a senior, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Medical conditions: If you have heart disease, high blood pressure, thyroid disease, narrow angle glaucoma, diabetes, or difficulty in urination due to enlargement of the prostate gland, you should not take this medication unless directed by a doctor.

Stomach ulcers and bleeding: Ibuprofen may cause ulcers or bleeding in the stomach or intestines. If you experience black, tarry stools, vomit that looks like coffee grounds, or stomach pain while taking this medication, contact your doctor immediately. If you have a history of stomach problems, discuss with your doctor or pharmacist how this medication may affect your medical condition and whether any special monitoring is needed.

Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication should not be used while breast-feeding.

Children: The caplets and liquid-gels should not be given to children less than 12 years old. The liquid form of the medication should not be given to children less than 6 years old.

Seniors: Seniors may be more likely to experience side effects from this medication.

There may be an interaction between ibuprofen – pseudoephedrine and any of the following:

acetylsalicylic acid (ASA)
anticoagulants (e.g., heparin, warfarin)
blood pressure medications (e.g., atenolol, ramipril, amlodipine)
corticosteroids (e.g., prednisone)
diabetes medications (e.g., glyburide and insulin)
diuretics (e.g., hydrochlorothiazide, furosemide)
herbs that may increase the risk of bleeding (e.g., cat’s claw, dong quai, feverfew, garlic, ginger)
MAO inhibitors (i.e., moclobemide, phenelzine)
other cold and allergy medications
other NSAIDs (e.g., naproxen, diclofenac, ketorolac)
SNRIs (e.g., desvenlafaxine, duloxetine, venlafaxine)
sodium salicylate
SSRIs (e.g., citalopram, escitalopram, fluoxetine, paroxetine, sertraline)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, and street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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